Adaptability is the key design driver for laboratories of the future

Managing Consultant, Decision Design, NNE

Henriette Schubert

Managing Consultant, Decision Design, NNE

Henriette Schubert is an expert in architecture, biocontainment and GMP facility design. With an emphasis on GMP demands and interdisciplinary biocontainment engineering, Henriette's key focus is on consulting assignments that target the basis for decision and basis for design, front-end studies and facility design concepts.

Henriette Schubert has worked with life science projects for most of her professional life and has acquired a profound knowledge and insight into interdisciplinary facility design for biocontainment and cGMP facilities. Today, Henriette also specializes in facilities for tailored therapies/personalized medicine, combining her laboratory operations experience with her insight into the synergies and conflicts between GMP and biocontainment.

Henriette Schubert has worked on pharma and biotech projects in Scandinavia, Europe, the USA, Russia, India and China. She has been a member of ABSA since 2007 and is also a member of the Nordic Biosafety Group, IVBWG (International Veterinary Work Group) and EBSA. Henriette is a regular speaker at conferences and symposiums.

Dealing with unknown future demands and rapid changeability is commonplace in this new pharma reality. Yet laboratories are often planned or even established before it is fully known which processes and technologies they actually need. The answer to this problem? Embracing flexible, modular laboratory facilities that can adapt to future research needs and process development.

The initial phases of a laboratory project are by far the most important. To be successful, you need a thorough understanding of the project, business objectives and motivations behind the design. You need to apply this same focused approach towards compliant and future-proof laboratory operations, whether you’re designing biopharmaceutical laboratories for research, development or quality control (QC).

In addition, the relationship between the laboratory product, laboratory processes and how the product is handled in operations is key to design. To approach this in the most efficient way, you need a comprehensive understanding of laboratory work processes, workflows and operations. You should then translate these aspects into programming, concept and laboratory design fit for purpose.

Updating your mindset to avoid redundant design

One current trend is that companies are investing in new laboratory facilities, or refurbishing current facilities, to improve flexibility – where main functions can be switched within weeks or even days. This is where modular concepts of flexible and mobile lab inventory and equipment become relevant.

Another trend is an increased focus on how laboratories are used. Traditionally, one of the fundamental objectives for laboratory design was to create space for a specific number of full-time employees. But severe pressure on the footprint of a laboratory facility means analysts, scientists and researchers can no longer have their own dedicated labs and equipment. There is a clear move away from “my lab” towards “our lab” – and an overall decrease in the size of laboratory facilities and lifecycle cost.

There is a clear move away from “my lab” towards “our lab” – and an overall decrease in the size of laboratory facilities and lifecycle cost."

Henriette Schubert

Therefore, staying stuck in an outdated mindset can make laboratory projects redundant from the outset. Organizations must adapt to a new business mindset of productivity, efficiency and creativity. And to match these business goals, they need to ensure future-proof and flexible laboratory concepts, with shared spaces and new ways of organizing.

This could include, for example, having centralized core facilities of high pressure liquid chromatography to serve the whole lab facility, rather than decentralized specialty functions with individual expert teams. Overall, it is important to evaluate the relevance and benefits of new technologies, and uncover the motivations behind design, laboratory requirements and needs for the future.

Transform into a laboratory of the future with technology

Technological development offers new opportunities across the board. For example, it is now possible to integrate QC sampling and analysis directly into process equipment. Therefore, when looking ahead to laboratories of the future, one key trend is a move towards integrating QC activities with manufacturing functions.

Another trend is new technology and operating methods trickling down to laboratory design. For example, the amount of digital data generated from laboratory processes is rocketing, and time spent on data handling is therefore significantly increasing. This influences work operations and laboratory concepts, meaning focused data handling and collaborative spaces need to be in future laboratory models.

Focused data handling and collaborative spaces need to be in future laboratory models.

Henriette Schubert

In addition, time spent on scientific collaborations and knowledge sharing is increasing and is expected to grow further with information technology and availability. Related to this, automated and integrated lab equipment, including robotics, are now used more than ever. And since robotic equipment rarely sits in work heavy areas, it therefore needs a simple, technical room with equipment to keep it cool.

All of these trends influence how laboratories work. Previously, lab workers spent around 60% of their time in a laboratory and 40% in support-related and write-up spaces. But going forward, with new laboratory design and new technology, only 20% of work time could be spent in the lab, and the remaining 80% on data handling, support functions and working in collaboration spaces.

Ultimately, laboratory automation and the growing emergence of robotics will transform the typical workday for laboratory technicians and scientists, and significantly alter the anatomy of the physical lab space.

How to move forward and prepare for an unknown future

With so many changes on the horizon, how can you successfully create sustainable and future-proof laboratory facilities?

First, it is key to take the right initial steps, and create a solid basis for decision and design. This could include using modular and generic laboratory concepts that can integrate future technologies down the line. It is also important to use an overall approach and avoid the mistake of customizing spaces based on past technologies and ways of working. And last but not least, you should conduct laboratory concept development in close cooperation and interaction with laboratory experts – the users – taking daily operations into all design considerations.